Topical tretinoin (Retin A)

What is Retin A?

Retin-A (pronounced Ret-in-A) and Renova (pronounced Re-NO-va) are brand names of the generic drug Tretinoin (TRET-i-noyn)

Retin-A is used in the treatment of acne. It is prescribed to treat acne vulgaris on facial skin.

Retin A is made from vitamin A, a fat-soluble vitamin that is absorbed through the intestines and stored in the liver. Vitamin A is important to maintaining healthy skin, mucous membranes, the intestinal lining, organs, immune system and the suppression of tumor growth.

How does Retin A work?

Apply at bedtime. Before you use this medicine, wash with a mild soap and dry the area gently. Wait 20 or 30 minutes before applying. Apply a thin film to the affected and surrounding area. Rub it in gently and wash your hands immediately afterward. Be sure to keep it away from your eyes, mouth, nose, and mucous membranes.

In the skin, it affects the depletion and dispersion of melanin as well as thickening and strengthening the tissues. Retin A increases blood vessel development and cell nutrition, decreases clogged pores and makes cells divide faster.

Side Effects of Retin A

Most published studies on topical tretinoin (Retin A) focus on the side effect of minor skin irritation.

Adverse dermatologic side effects commonly reported are an unusual darkening of the skin or lack of color of the skin may occur temporarily with repeated application of Avita or Retin-A.

Side effects of Renova are generally not severe and may include burning, dry skin, itching, peeling, redness, and stinging.

These cutaneous irritant side effects, while noted in up to 50% of treated patients, peaked in 7 days and decreased significantly over time.

Topical tretinoin has been in clinical use for more than 25 years. Topical delivery results in a very low systemic exposure; plasma retinoid levels measured after topical use remain at or below endogenous levels, likely due to very limited absorption. Topical tretinoin is not associated with an increased risk for major congenital disorders. A retrospective study of 215 women on tretinoin during the first trimester compared with 430 controls found that the relative risk for a major congenital anomaly was 0.7 (95% CI, 0.2-2.3). The authors concluded that topical tretinoin did not increase congenital anomaly risk.

If you have eczema (skin inflammation consisting of itching and small blisters that ooze and crust over) or other chronic skin conditions, use with extreme caution, as they may cause severe irritation.

If you have sensitive skin, the use of Retin-A may cause your skin to become excessively red, puffy, blistered, or crusted. If this happens, notify your doctor, who may recommend that you discontinue the medication until your skin returns to normal, or adjust the medication to a level that you can tolerate.

What are the symptoms of overdose?

If it causes an abnormal irritation, redness, blistering, or peeling of the skin, notify your doctor. He may suggest that you use the medication less frequently, discontinue use temporarily, or discontinue use altogether. If a severe sensitivity reaction or chemical irritation occurs, you will probably need to stop using the drug and notify your doctor.

If you miss a dose of Retin A

If you miss a dose... Resume your regular schedule the next night.

Conditions you should tell your Doctor about before taking Retin A:

If you are pregnant or plan to become pregnant, do not use Retin A.

It is not known whether the drug appears in breast milk. Use with caution when breast feeding.

During the early weeks of acne therapy, a worsening of the condition may occur due to the action of Avita or Retin-A on deep, previously unseen areas of inflammation. This is not a reason to discontinue therapy, but do notify your doctor if it occurs.

Tell Your Doctor if you're taking any of the following medicines:

Do not use Renova if you are taking other drugs that increase sensitivity to sunlight. These include:

Certain antibiotics, including Cipro, Noroxin, and tetracycline
Major tranquilizers such as Thorazine and Mellaril
Sulfa drugs such as Bactrim and Septra
Thiazide drugs (water pills) such as Diuril and HydroDIURIL

If these medications are used with certain other drugs, the effects could be increased, decreased, or altered. It is especially important to check with your doctor before combining Retin-A with the following:
Preparations containing benzoyl peroxide, such as Benzac AC Wash 5, Benzshave Desquam-E, PanOxyl
Preparations containing sulfur (ointments and other preparations used to treat skin disorders and infections)
Resorcinol (a drug, used in ointments to treat acne, that causes skin to peel)
Salicylic acid (a drug that kills bacteria and fungi and causes skin to peel)

Caution should be exercised when using Retin-A in combination with other topical medications:
Medicated or abrasive soaps and cleansers
Soaps and cosmetics that have a strong drying effect
Products with high concentrations of alcohol
Astringents
Spices or lime (especially the peel)
Permanent wave solutions
Electrolysis
Hair depilatories or waxes
Other preparations that may dry or irritate the skin.

Storing Retin A

Store at ordinary room temperature. Do not freeze.

General Notes

"Resting" your skin is recommended between use of the above preparations and treatment with Retin-A.

You should begin to notice results after 2 to 3 weeks of treatment. More than 6 or 7 weeks of treatment are needed before consistent beneficial effects appear.

Applying Retin-A excessively will not produce faster or better results, and marked redness, peeling, or discomfort could occur.

Once acne has responded satisfactorily, it may be possible to maintain the improvement with less frequent applications or other dosage forms. Any change in formulation, drug concentration, or dose frequency should be closely monitored by your doctor. This is to determine your tolerance and response.

While using Retin-A, keep exposure to sunlight, including sun lamps, to a minimum. If you have a sunburn, do not use the medication until you have fully recovered. Use of sunscreen products (at least SPF 15) and protective clothing over treated areas is recommended when exposure to the sun cannot be avoided. Weather extremes, such as wind and cold, may be irritating and should also be avoided while using these products.

Retin-A should be applied once a day, at bedtime, to the skin where acne appears, using enough to lightly cover the affected area. The liquid form may be applied using a fingertip, gauze pad, or cotton swab. If you use gauze or cotton, avoid over saturation, which might cause the liquid to run into areas where treatment is not intended.

You may use BIOSKINCARE to releive the side effects while being treated, however, you should thoroughly cleanse the areas to be treated before applying the medication.

If there is no immediate improvement, or new blemishes appear, don't get discouraged. It takes weeks for the medicine to take effect. Continue applying the prescribed amount. (Do not increase the dosage; it may irritate your skin.)

Do not stop treatment when improvement finally occurs. You must continue therapy to maintain the beneficial effect.

Retin-A gel and Avita are flammable and should be kept away from heat and flame.

Common Misspellings for Retin-A

Retin-A is often misspelled, as many people hear the word verbally, write it down and spell it incorrectly. Here are a few of the most common misspellings for Retin-A: Retna-A, Retin, Retin Microb, and Retan A.

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